研究業績

2025年

原著論文

• "Polysulfide and persulfide-mediated activation of the PERK-eIF2α-ATF4 pathway increases sestrin2 expression and reduces methylglyoxal toxicity "
  Shin Koike, Hideo Kimura, Yuki Ogasawara
  Redox Biology 79, 103450 (2025).

  • URL
• "Inhibition of amyloid β aggregation and BACE1, and protective effect on SH-SY5Y cells, by p-terphenyl compounds from mushroom Thelephora aurantiotincta."
  Shuntaro Hirabayashi, Koji Fujihara, Takehito Saito, Hiroaki Sasaki, Shin Koike, Yuki Ogasawara, Kiyotaka Koyama, Kaoru Kinoshita
  Journal of natural medicines 79, 1, 268-277 (2025).
• "Dimethyl Fumarate Reduces Methylglyoxal-derived Carbonyl Stress Through Nrf2/GSH Activation in SH-SY5Y Cells."
  Shin Koike, Satori Tsurudome, Saki Okano, Atsushi Kishida, Yuki Ogasawara
  Neurochemical research 50, 1, 28-28 (2025).

  • URL

2024年

原著論文

• "Elucidating the Antiglycation Effect of Creatine on Methylglyoxal-Induced Carbonyl Stress In Vitro"
  Shin Koike, Haruka Mitsuhashi, Atsushi Kishida, Yuki Ogasawara
  International Journal of Molecular Sciences 25, 20, 10880 (2024).

  • URL

総説

• "Analysis and characterization of sulfane sulfur"
  Shin Koike, Yuki Ogasawara
  Analytical biochemistry 687, 115458-115458 (2024).

2023年

原著論文

• "Novel fluorometric assay of antiglycation activity based on methylglyoxal-induced protein carbonylation"
  Koike S, Saito Y, Ogasawara Y
  Antioxidants (Basel) 12, 2030 (2023).

総説

• "Methylglyoxal, which is also produced by the oxidation of glycerol, a moisturizing component, produce carbonylated collagen in the skin"
  Koike S, Sugiura K, Ogasawara Y
  IMARS HIGHLIGHTS 18, 5-8 (2023).

著書

• "3-Mercaptopyruvate sulfurtransferase: a review of past and present perspectives"
  Yuki Ogasawara
  Essential Enzymes for Life (Foundations and Frontiers in Enzymology)1st Ed. eBook, pp.55-65, Academic　Press, Elsevier (2023).

2022年

原著論文

• "Hyperoxidized Peroxiredoxin 2 Is a Possible Biomarker for the Diagnosis of Obstructive Sleep Apnea"
  Koike S, Sudo H, Turudome S, Ueyama M, Tanaka Y, Kimura H, Ishida YI, Ogasawara Y
  Antioxidants (Basel) 11, 2486 (2022).
• "Exposure to Heated Tobacco Products Aerosol Causes Acute Stress Responses in the Lung of Mouse"
  Koike S, Sato K, Sawa M, Inaba Y, Hattori K, Nakadate K, Ushiyama A, Ogasawara Y
  Antioxidants (Basel) 11, 2329 (2022).
• "Plasma unconjugated bile acids as novel biomarker for schizophrenia"
  Koike S, Miyaji Y, Suzuki K, Miyashita M, Itokawa M, Arai M, Ogasawara Y
  Biochem. Biophys. Res. Commun. 634, 70-74 (2022).
• "Carbonylation of skin collagen induced by reaction with methylglyoxal"
  Sugiura K, Koike S, Suzuki T, Ogasawara Y
  Biochem. Biophys. Res. Commun. 562, 100-104 (2022).
• "Alkaline stress inhibits the growth of Staphylococcus epidermidis by inducing TCA cycle-triggered ROS production"
  Ohkubo T, Matsumoto Y, Ogasawara Y, Sugita T
  Biochem. Biophys. Res. Commun. 588, 104-110 (2022).
• "Inhibition of Amyloid-β aggregation by p-terphenyls from the mushroom Polyozellus multiplex and their neuroprotective effects"
  Nakabayashi S., Ishikura A., Fujihara K, Hirabayashi S., Koike S., Sasaki H, Ogasawara Y. Koyama K, Kinoshita K
  Heterocycles 104, 2025-2036 (2022).
• "Exposure to aerosol extract from heated tobacco products causes a drastic decrease of glutathione and protein carbonylation in human lung epithelial cells"
  Nishimoto-Kusunose S, Sawa M, Inaba Y, Ushiyama A, Ishii K, Hattori K, Ogasawara Y
  Biochem. Biophys. Res. Commun. 580, 92-99 (2022).

2021年

原著論文

• "Delftia acidovorans secretes substances that inhibit the growth of Staphylococcus epidermidis through TCA cycle-triggered ROS production"
  Ohkubo T, Matsumoto Y, Cho O, Ogasawara Y, Sugita T
  PloS one 16, 7, e0253618 (2021).
• "Accumulation of Carbonyl Proteins in the Brain of Mouse Model for Methylglyoxal Detoxification Deficits"
  Koike S, Toriumi K, Kasahara S, Kibune Y, Ishida YI, Dan T, Miyata T, Arai M, Ogasawara Y
  Antioxidants (Basel, Switzerland) 10, 4, 574 (2021).
• "A newly developed aerosol exposure apparatus for heated tobacco products for in vivo experiments can deliver both particles and gas phase with high recovery and depicts the time-dependent variation in nicotine metabolites in mouse urine"
  Sawa M, Ushiyama A, Inaba Y, Uchiyama S, Hattori K, Ogasawara Y, Ishii K
  Nicotine Tob Res. 23, 12, 2145-2152 (2021).
• "Carbonylation of skin collagen induced by reaction with methylglyoxal"
  Sugiura K*, Koike S*, Suzuki T, Ogasawara Y
  Biochem Biophys Res Commun. 562, 100-104 (2021).
• "Simultaneous Determination of Five Bile Acids as Potential Biomarkers for Alzheimer's Disease in Mouse Brain and Plasma"
  Koike S, Miyaji Y, Sano H, Aikawa N, Kai M, Kasahara S, Suzuki T, Nishimoto-Kusunose S, Ogasawara Y
  Anal Sci. 37, 8, 1165-1170 (2021).
• "Effects of osmolality on the expression of brain aquaporins in AQP11-null mice"
  Koike S, Tanaka Y, Morishita Y, Ishibashi K
  Biochimie. 188, 2-6 (2021).
• "Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex"
  Toriumi K, Berto S, Koike S, Usui N, Dan T, Suzuki K, Miyashita M, Horiuchi Y, Yoshikawa A, Asakura M, Nagahama K, Lin HC, Sugaya Y, Watanabe T, Kano M, Ogasawara Y, Miyata T, Itokawa M, Konopka G, Arai M
  Redox biology 45, 102057 (2021).

2020年

原著論文

• "Excessively activated plasminogen in human plasma cleaves VWF multimers and reduces collagen-binding activity"
  Togashi K, Suzuki S, Morita S, Ogasawara Y, Imamura Y, Shin Y
  J Biochem. 168, 355-363 (2020).
• "Oxidative Formation of Methylglyoxal in Glycerol Preparations during Storage"
  Sugiura K, Koike S, Suzuki T, Ogasawara Y
  Biol Pharm Bull. 43, 879-883 (2020).
• "Complete Genome Sequence of Citrobacter koseri Strain MPUCK001"
  Ohkubo T, Matsumoto Y, Cho O, Ogasawara Y, Sugita T
  Microbiology resource announcements 9, 50 (2020).

2019年

原著論文

• "Differential oxidation processes of peroxiredoxin 2 dependent on the reaction with several peroxides in human red blood cells"
  Ishida YI, Ichinowatari Y, Nishimoto S, Koike S, Ishii K, Ogasawara Y
  Biochem. Biophys. Res. Commun. 518, 685-690 (2019).
• "Troglitazone Impedes the Oligomerization of Sodium Taurocholate Cotransporting Polypeptide and Entry of Hepatitis B Virus Into Hepatocytes"
  Fukano K, Tsukuda S, b Oshima M, Suzuki R, Aizaki H, Ohki M, Park SY, Muramatsu M, Wakita T, Sureau C, Ogasawara Y, Watashi K
  Front. Microbiol. 9, 3257 (2019).
• "Age-related alteration in the distribution of methylglyoxal and its metabolic enzymes in the mouse brain"
  Koike S, Ando C, Usui Y, Kibune Y, Nishimoto S, Suzuki T, Ogasawara Y
  Brain Res. Bull. 144, 164-170 (2019).

2018年

原著論文

• "De Novo Macrocyclic Peptide Inhibitors of Hepatitis B Virus Cellular Entry"
  Passioura T, Watashi K, Fukano K, Shimura S, Saso W, Morishita R, Ogasawara Y, Tanaka Y, Mizokami M, Sureau C, Suga H, Wakita T
  Med. Mycol. J. 59, E47-E52 (2018).
• "Identification of Heparin-binding Proteins on the Cell Surface of Cryptococcus neoformans"
  Nagahara N, Koike S, Nirasawa T, Kimura H, Ogasawara Y
  Biochem Biophys Res Commun 496, 648-653 (2018).

2017年

原著論文

• "Polysulfides (H2Sn) produced from the interaction of hydrogen sulfide (H2S) and nitric oxide (NO) activate TRPA1 channels "
  Ryo Miyamoto, Shin Koike, Yoko Takano, Norihiro Shibuya, Yuka Kimura, Kenjiro Hanaoka, Yasuteru Urano, Yuki Ogasawara, Hideo Kimura
  SCIENTIFIC REPORTS 7 45995 7, 45995 (2017).
• "Inhibition of amyloid β aggregation and protective effect on SH-SY5Y cells by triterpenoid saponins from the cactus Polaskia chichipe. "
  Fujihara K, Koike S, Ogasawara Y, Takahashi K, Koyama K, Kinoshita K
  Bioorganic & medicinal chemistry 25, 13, 3377-3383 (2017).
• "Cysteine persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation "
  Shin Koike, Shoichi Nishimoto, Yuki Ogasawara
  REDOX BIOLOGY 12, 530-539 (2017).
• "3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H2S2, H2S3 and H2S "
  Yuka Kimura, Shin Koike, Norihiro Shibuya, David Lefer, Yuki Ogasawara, Hideo Kimura
  SCIENTIFIC REPORTS 7, 1, 10459 (2017).
• "Identification of an argpyrimidine-modified protein in human red blood cells from schizophrenic patients: A possible biomarker for, diseases involving carbonyl stress "
  Y. I. Ishida, T. Kayama, Y. Kibune, S. Nishimoto, S. Koike, T. Suzuki, Y. Horiuchi, M. Miyashita, M. Itokawa, M. Arai, Y. Ogasawara
  Biochem Biophys Res Commun 493, 1, 573-577 (2017).
• "Analysis of endogenous H2S and H2Sn in mouse brain by high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection "
  Shin Koike, Kumiko Kawamura, Yuka Kimura, Norihiro Shibuya, Hideo Kimura, Yuki Ogasawara
  FREE RADICAL BIOLOGY AND MEDICINE 113 , 355-362 (2017).
• "Activation of Nrf2 attenuates carbonyl stress induced by methylglyoxal in human neuroblastoma cells: Increase in GSH levels is a critical event for the detoxification mechanism"
  Nishimoto S, Koike S, Inoue N, Suzuki T, Ogasawara Y
  Biochem Biophys Res Commun 483, 2, 874-879 (2017).

2016年

総説

• "Sulfur Atom in its Bound State Is a Unique Element Involved in Physiological Functions in Mammals "
  Shin Koike, Yuki Ogasawara
  MOLECULES 21, 12 (2016).